Notch Signaling Pathway

Oct-4 Self-renewal

The Notch Signaling Pathway is essential for maintaining brain.
Modulators of notch signal can halt cell cycle. Notch signal controls
Neural Progenitor Cell. Self-Renewal as well as cell blocking depends on Notch Signaling Pathway.

Reference Table

http://en.wikipedia.org/wiki/Adult_stem_cell

http://en.wikipedia.org/wiki/Oct-4

Steve Watkins, Ph.D., Chief Technology Officer
Lipomics, 3410 Industrial Blvd Suite #103
West Sacramento, CA 95691 USA
530-400-8155
swatkins@metabolon.com 

http://www.metabolon.com/services/Technology.aspx

New Economics

by Kaushik Basu

No human beings appear in the flesh in Kaushik Basu's Beyond The Invisible Hand: Groundwork for a New Economics ; there are only the intellectual ghosts of dead ones, particularly Adam Smith, whose ideas about the workings of markets and morality have been claimed and in many instances radically damaged by free-market thinkers of our time. But Basu has a wonderfully wry sense of humour, an eye for local examples for universal laws, and an argumentative style so rigorous and yet unassuming -- consider the use of the word "groundwork" in his title -- that the three hundred or so pages of his book left me wanting much more. So I read it twice. The book is an elegant and unpartisan meditations on one of the great issues of our age: markets and their limits, and offers a roadway to rescuing free-market thinking from its more fanatical adherents. Chapter 1 of the book is here; you couldn't improve your brain more for an investment of Rs. 303. Basu's Twitter feed is consistently good reading too.






http://press.princeton.edu/chapters/s9299.pdf

Cord Blood Bank for Stem Cell

The Benefits of Stem Cell Preservation

Stem cell preservation is a medical breakthrough with immense possibilities for mankind. Expectant mothers, in particular, maybe very interested in collecting cord blood, because this blood may be used in the future to cure life-threatening conditions not only for the baby, but also potentially for its siblings and possibly unrelated recipients. There is absolutely no risk involved for the mother and child during cord blood collection for the stem cell preservation process.

In addition to cord blood stem cells being used to treat over 40 different diseases and disorders ranging from blood cancers to immune disorders, stem cells in general are currently being studied, with great success, in treating a myriad of diseases and disorders such as Alzheimer’s, Parkinson’s, stroke, heart disease, Type 1 diabetes, Cerebral Palsy, spinal cord injuries and organ regeneration.

IBM Research and Development

LASIK

This achievement is a reflection of IBMs culture of innovation, to think far into the future, and a result of enabling different disciplines to come together to tackle real-world challenges with a broad domain of expertise, said Dr Wynne of IBM Research.

In 1981, Srinivasan discovered that an ultraviolet excimer laser could etch living tissue in a precise manner with no thermal damage to the surrounding area. He named the phenomenon Ablative Photo-decomposition (APD), which later revolutionized eye surgery.

Inducted into the US Inventor Hall of Fame in 2002, Srinivasan has spent 30 years at IBMs T J Watson Research Center. He received both bachelors and masters degrees in science from the University of Madras, in 1949 and 1950. He earned doctorate in physical chemistry at the University of Southern California in 1956. He currently holds 21 US patents.

http://indiatoday.intoday.in/story/barack-obama-honours-nri-scientist-rangaswamy-srinivasan-laser-treatment/1/248587.html

Crosscut Saw

Albert King

As an electric guitar player who focused more on tone and intensity than flash, Albert King had a tremendous impact on countless rock and roll guitarists, including Eric Clapton, Jimi Hendrix, Michael Bloomfield and Stevie Ray Vaughan. King was also one of the first bluesmen who crossed over into the world of soul music, signing with Stax Records and recording such classic songs as “Born Under a Bad Sign” and “Crosscut Saw.”

Albert King was born Albert Nelson on April 25, 1923, in Indianola, Mississippi, the same town where B.B. King grew up. As a child, he sang with his family’s gospel group at a church where his father played the guitar. When King was eight, his family moved to Forrest City, Arkansas, and he would pick cotton on plantations in the area. Around that same time, King bought his first guitar, paying only $1.25. His first inspiration was T-Bone Walker.

http://www.youtube.com/watch?v=mMDXikzO-BI

World Railway Station

Today is the centennial of Grand Central Terminal, the nation's most iconic -- and certainly its most beautiful -- train station.

The idea is that passengers rushing to catch trains they're about to miss can actually be dangerous -- to themselves, and to each other. So conductors will pull out of the station exactly one minute after their trains' posted departure times. That minute of extra time won't be enough to disconcert passengers too much when they compare it to their own watches or smartphones ... but it is enough, the thinking goes, to buy late-running train-catchers just that liiiiiitle bit of extra time that will make them calm down a bit. Fast clocks make for slower passengers. "Instead of yelling for customers to hurry up," the Epoch Times notes, "the conductors instead tell everyone to slow down." 

The Atlantic
http://bit.ly/ToW9vh

http://www.funzug.com/index.php/travel/10-most-beautiful-train-stations-in-the-world.html

Nobel Prize 2013

Malala Yousafzai has been nominated for this year's Nobel Peace Prize. The deadline for nominations was today. French, Canadian and Norwegian MPs have all separately nominated Malala. 

A crucial operation to cover her skull with a special titanium patch is scheduled in next ten days. The 14-year-old will have a specially made titanium plate fitted to her skull, followed by a cochlear implant to help her recover hearing in her left ear.

India Project Execution - Bill Gates Interview

Kerala achieved good results from Gate's foundation

In India it is still about money but it is more about execution, whether it is in education, which is not a big area for us, or health, which is a big area. The quality of execution is a limiting factor. Kerala achieved great health results not so much by putting a lot more money in than in other places; or if you look at the improvements in Bihar in the last four years, they used some of their NRHM money but that really was about measurement and quality of execution.

http://bit.ly/11veshf

www.billsletter.com

Notes: 

Work & Life Style Management training

1. Database training

2. Public relation training


The pneumococcus bacterium (Streptococcus pneumoniae) kills approximately 500,000 children less than five years of age each year, mainly in the developing world. It is the leading cause of childhood pneumonia, the number one killer of children under five in the developing world, and a cause of meningitis (inflammation of the covering of the brain), ear infections, and bacteremia (blood stream infection). Pneumococcal disease can be treated with antibiotics; however, antibiotic-resistant strains are becoming more common worldwide. Current pneumococcal vaccines approved for use in children are effective against strains common in the industrialized world and some developing countries, but do not cover all 90+ pneumococcal serotypes and they are complex and expensive to manufacture. There are several additional vaccines in development.

Tamil

Ontology

In theory, an ontology is a formal, explicit specification of a shared conceptualization. An ontology renders shared vocabulary and taxonomy which models a domain with the definition of objects and/or concepts and their properties and relations.

Ontologies are the structural frameworks for organizing information and are used in artificial intelligence, the Semantic Web, systems engineering, software engineering, Biomedical Informatics, library science, enterprise bookmarking, and information architecture as a form of knowledge representation about the world or some part of it. The creation of domain ontologies is also fundamental to the definition and use of an enterprise architecture framework.

wiki

Ontology based bilingual search

Lourdu Sophia A <sophiasebastin@gmail.com>

http://slidesha.re/WIfLuf